Product introduction
Afatinib (100 nM) sufficiently prevents heregulin-stimulated HER3 phosphorylation[1].
Afatinib (0-10000 nM) effectively inhibits anchorage-independent proliferation of NIH-3T3 cells ectopically expressing EGFR mutants, and inhibits cell proliferation of H1666, H3255, and NCI 1975 cells[1].
Afatinib (48-72 h)shows growth inhibition in HKESC-1, HKESC-2, SLMT-1 and EC-1 cells[2].
Afatinib (0-1 μM, 24-48 h) inhibits AKT and MAPK pathways, and inhibits EGFR and AKT phosphorylation in ESCC cell lines[2].
Afatinib (0-1 μM, 16-48 h) induces G0/G1 cell cycle arrest in HKESC-2 and EC-1[2].
Afatinib (0-1 μM, 24-48 h) effectively induces apoptotic cell death in HKESC-2 and EC-1[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Product Name: | Afatinib | ||
Product Code: | TY2018003 | ||
Cas No.: | 850140-72-6 | ||
Molecular Formula: | C24H25N5O3FCl | ||
Molecular Weight: | 485.9384 | ||
Purity: | 99% | ||
Appearance: | white powder |